Biodegradable Metal-organic Frameworks Composites as Antifouling Coating

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dc.contributor.authorKottan, Nihal
dc.contributor.departmentChalmers tekniska högskola / Institutionen för life sciencessv
dc.contributor.departmentChalmers University of Technology / Department of Life Sciencesen
dc.contributor.examinerMijakovic, Ivan
dc.contributor.supervisorCao, Zhejian
dc.date.accessioned2023-06-19T13:59:59Z
dc.date.available2023-06-19T13:59:59Z
dc.date.issued2023
dc.date.submitted2023
dc.description.abstractBiofilms created by bacteria can cause severe problems in healthcare facilities and the marine industry. Biofilms impact the effectiveness of antibacterial strategies and enhance the infectious capability of pathogenic bacteria. Growth cooperation among marine organisms on biofilms leads to biofouling, resulting in increased fuel expenditure and loss of function in marine structures. Several examples of mechanobactericidal materials like vertically oriented graphene, nanorods, etc. have been reported to reduce biofilm formation. These coatings are manufactured using methods that are usually unsuitable and expensive for deployments on large surfaces. In this thesis, we aim to explore the mechano-bactericidal capability of metal-organic frameworks (MOFs) synthesized using solvothermal method, embedded in biodegradable polymers, such as polycaprolactone and poly-3-hydroxybutyrate, to develop antibacterial composites. MOFs like MIL-88B and UiO-66@MIL-88B possess highly defined edges that can potentially rupture cell membranes. Both selected polymers are enzymatically degraded by bacteria, show good resistance to hydrolytic degradation, and are biocompatible. In theory, the degradation of the polymer would clean the composite surface and expose incoming cells to a fresh layer of MOFs. Pseudomonas aeruginosa (PA) and Staphylococcus epidermis (SE) were used to evaluate antibacterial capability, as both bacteria are common pathogens that cause severe infections in mammals. PA is commonly found in marine environments and is reported to degrade both selected polymer matrices. Colony-forming unit experiments evaluating antibacterial efficacy indicated that the tested MOFs could deactivate a large portion of both Gram-positive and negative inoculum used to test the composite and scanning electron microscope (SEM) images confirmed the physical penetration of bacterial cell membranes by MOFs. PA biofilm-induced degradation was studied at multiple time points using SEM to observe surface changes in the materials. The results indicate that the MOF-polymer composites are good candidates to reduce biofilm formation, and with refinement, could potentially be used as antifouling or medical device coatings.
dc.identifier.coursecodeBBTX03
dc.identifier.urihttp://hdl.handle.net/20.500.12380/306298
dc.language.isoeng
dc.setspec.uppsokLifeEarthScience
dc.subjectMetal-organic frameworks
dc.subjectantifouling
dc.subjectantibacterial coatings
dc.subjectbiodegradable polymers
dc.subjectmechano-bactericidal
dc.subjectPseudomonas aeruginosa
dc.titleBiodegradable Metal-organic Frameworks Composites as Antifouling Coating
dc.type.degreeExamensarbete för masterexamensv
dc.type.degreeMaster's Thesisen
dc.type.uppsokH
local.programmeMaterials engineering (MPAEM), MSc
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